mGlu5: A double-edged sword for aversive learning related therapeutics

Aversive memories underlie many types of anxiety disorders. One area research to more effectively treat disorders has therefore been identifying pharmacological targets affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) received attention due availability drugs utilize its role in learning and memory. In this review, we highlight preclinical studies examining mGlu5 at various stages aversive inhibition via extinction order gain a better understanding therapeutic potential. We suggest that distinct roles different not only makes it tricky target, but double-edged sword as therapeutic. However, selective involvement allows for certain precision could be harnessed clinically. potential applications, limitations, pitfalls when considering use modulators therapeutics. addition, recommend future address important gaps literature, such sex age factors light being prevalent those demographics.